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the administration of the methylcobalamin will be particularly easy and effective to administer as the dosing is such that it can be administered in a spray

8A) and significantly decreased RNS levels by more than 50% (Fig

It performs best as an adjunct, not a replacement

Explore novel modalities such as PROTACs (targeting ACSL4 and Nrf2), gene therapies (e.g., AAV-mediated SLC7A11 overexpression in PT cells), and epigenetic modulators (e.g., m 6 A inhibitors that regulate ferroptosis-related gene expression)

However, the role of mitophagy regulators such as PINK1/PRKN, BNIP3, and NIX in pancreatic tumorigenesis and progression is dynamic and intricate, as demonstrated in transgenic PDAC mouse models [53, 58]

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