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doi: 10.3390/biomedicines9101476 175 SazdovaIKeremidarska-MarkovaMDimitrovaDMitrokhinVKamkinAHadzi-PetrushevNet al

10.1016/j.ekir.2021.05.012 Kidney Int Rep

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Persons Receiving Chemotherapy and Immunomodulatory Therapies : Receipt of chemotherapy, or other anticancer immunomodulatory therapy, including immune checkpoint inhibitors and tyrosine kinase inhibitors, for solid and/or liquid tumors is a well-described risk factor for HBV reactivation.[8,9,10,11] Although the risk of reactivation depends on the individuals HBsAg status and the specific chemotherapy used, the risk of reactivation may be as high as 50 to 60% among HBsAg-positive persons who receive CD20-depleting agents without antiviral prophylaxis.[8,12] Individuals Receiving Treatment for Autoimmune Disease or Other Conditions Requiring Immunomodulatory Therapy : Individuals receiving immunomodulatory medications, regardless of the underlying indication, for the treatment of autoimmune disease are also at risk for HBV reactivation