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doi:10.1016/j.beem.2018.06.007 Wilding JPH, Batterham RL, Calanna S, et al

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In addition, PRI-724, a Wnt signaling pathway inhibitor, has demonstrated its efficacy and safety in an earlier solid tumor clinical trial (NCT01302405), but no clinical trial has yet evaluated its clinical value in the treatment of HCC patients

Future studies should consider incorporating complementary methods, such as p62/SQSTM1 or electron microscopy, to achieve a more accurate and comprehensive evaluation