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GPX4 has been found at high levels in cancer cells and contributes to drug-resistance against lapatinib, palbociclib and other anti-cancer drugs

Metformin induces apoptosis via the downregulation of the downstream targets of K-RAS in human A549 lung adenocarcinoma cells with K-RAS mutations (67)

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doi: 10.1016/s1058-2746(96)80066-8

The most recent data from 2025 continues to solidify oxidative stress as the shared mechanistic basis for post-viral syndromes

IL-4 plays a crucial role in establishing an immunosuppressive TME by promoting macrophage polarization toward an M2-like phenotype, which contributes to ICB resistance in OvCa