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Artesunate induces ER-derived-ROS-mediated cell death by disrupting labile iron pool and iron redistribution in hepatocellular carcinoma cells

This observation is comparable to study findings from China (59), Portugal (27), and Japan (26) but is incongruent with another study finding reported from Japan (60)

The practical research implication is substantial: studies using ipamorelin to investigate GH/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable

H152 and active site residues C46, K48, Q81, and W136 are highlighted and shown as sticks

doi: 10.3389/fcell.2025.1623959 Received 06 May 2025 Accepted 04 August 2025 Published 20 August 2025 Volume 13 - 2025 Edited by Valerie Kouskoff, The University of Manchester, United Kingdom Reviewed by Soumya Ranjan Jena, Ravenshaw University, India Vinod Reddy Lekkala, University of California, San Francisco, United States Updates Copyright 2025 Feng and He

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