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[11] Healthy Aging As we age, glutathione levels naturally decline, which can contribute to increased cellular damage and inflammation

129 Additionally, the brain is affected by the hormone leptin, which is released by fat cells and regulates overall energy balance by reducing food intake and increasing energy utilization

[PMC free article: PMC4475484] [PubMed: 25904598] 121

EC 1.1.1.27) is a family of oxidoreductases that catalyze the reversible conversion of pyruvate, the conjugate base of pyruvic acid, to lactate, with the concomitant interconversion of NADH and NAD + , which act as cofactors