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Among genetic predispositions, specific human leukocyte antigen (HLA) genes are strongly implicated, such as HLA-B51 in BD ( Figure 1 ) ( Figure 1 Based on current evidence, we hypothesize that dysbiosis of the gut microbiome and its metabolites trigger gut inflammation and increase intestinal permeability (leaky gut)

Acknowledgements We thank Kevin Vogt for helpful assistance in the preparation of this manuscript

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