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273 Moreover, GLP-1RAs could decelerate the progression of OA and mitigate pathological damage in a rat OA model

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As with all GLP-1 agonists, long-term post-marketing surveillance will be essential to characterize the pancreatic safety profile with greater statistical precision, particularly for rare events such as acute pancreatitis (estimated background rate of approximately 35 per 100,000 person-years in the general population) and the theoretical concern about pancreatic cancer

These are cautious recommendations because data are sparse

Liver detoxification is more accurately called biotransformation and elimination

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