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Finally, we previously used an animal experiment to show that RGC loss in Nrf2 knockout mice was much faster after optic nerve damage was induced by crushing the nerve 41

3 Results 3.1 Identification of OS-DEGs in response to INH The analysis of transcriptomic results of INH-treated HepG2 cells compared to untreated controls revealed 7,202 DEGs out of a total of 16,921 genes (Figure 1A)

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