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Naltrexone, in a very low dose (typically 1.5 to 4.5 mg), briefly blocks opioid receptors in the brain and on immune cells for a few hours overnight

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The most common side effect is minor swelling or redness from the needle used in the injection

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Sit on a bed with legs extended

Most treatment protocols run between 4 and 12 weeks, and patients often find that benefits like reduced pain, faster healing, and improved mobility persist for several months after the final injection