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Organ Fibrosis Investigated for its ability to target senescent myofibroblasts in pulmonary and renal fibrosis models

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Diabetes 63 (10), 32793294

ZhangHHeZChenYChaoJChengXMaoJet al

NMR DNA titration experiments, computational modelling, phylogenetic conservation and Escherichia coli -based activity assays combine to suggest a DNA-binding model in which a brim of positively charged residues positions the target cytosine for catalysis