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Conventional medical approaches to treating Parkinson's disease aim to replace the lost dopamine, but fall short of addressing the ongoing destruction of dopaminergic neurons

Autophagic pathways in Parkinson disease and related disorders

doi:10.1038/s41398-019-0466-x Lyte M, Daniels KM, Schmitz-Esser S

MDVs are transported to peroxisomes via the outer membrane mitochondrial anchoring protein ligase (MAPL) or are trafficked to lysosomes via the Parkin pathway, binding to lysosomes that degrade their cargoes [53]

As shown in Figure 6D, GO enrichment analysis revealed that immune response, immune system process, and defense response were the top three signaling pathways suppressed in the DSS-MSC group