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Distribution, Biosynthesis, and Disease Associations Glutathione is found both intracellularly and in the extracellular matrix, with particularly high levels in: Lung tissue Brain tissue Liver tissue It is synthesized endogenously through a two-step enzymatic pathway involving -glutamylcysteine synthetase and glutathione synthetase

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Strenuous exercise triggers a rapid and large increase in IL-6 and TNF- levels post-exercise, which can last for around 24 hours, particularly after extreme events like ultramarathons and triathlons where IL-6 and TNF- levels significantly surpass baseline values (182, 183)

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