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Mass spectrometry-based proteomics reveals that these off-targets are highly abundant proteins (e.g

Vitamin C, a well-known antioxidant, enhances the sensitivity of cancer cells resistant to imatinib by disrupting the Nrf2/ARE complex, resulting in decreased expression of the catalytic subunit of glutamate-cysteine ligase and lower GSH levels (175)

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Between 2010 and 2015, formulation advancements, such as the use of hyaluronidase (rHuPH20) co-formulation, enabled higher concentration SC products and improved absorption [9, 10]