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Figure 2 6 Pathologic relationship between ferroptosis and neurodegenerative diseases The hallmark of neurodegenerative diseases is the gradual death of neurons and are brought on by an accumulation of oligomers and aggregates of misfolded proteins (Menzies et al., 2020)

[3] Infection by Helicobacter pylori which increases the production of reactive oxygen and nitrogen species in human stomach is also thought to be important in the development of gastric cancer

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[16] Only a small subset of dementia cases are reversible with vitamin B 12 therapy

The GCH1/BH 4 /DHFR system suppresses ferroptosis The metabolic change that occurs in cancer cells often requires endogenous antioxidants to reduce toxic lipid oxidation