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These proteins are implicated in mitosis, fatty acid metabolism, p53-dependent apoptosis and complex I of the mitochondrial respiratory chain, respectively ( Supplementary Table S1 )

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2 Goal-based orientation to peptide category selection

Activation of the UPR increases the expression of the cytokines interleukin (IL)-6 and IL-8 by stressed melanocytes [74] and the release of C-X-C chemokine ligand (CXCL) [27,28,34], which mediate T-cell homing to the skin in vitiligo [75], and the production of CXCL16 from stressed keratinocytes that recruits cluster of differentiation 8-positive (CD8 + ) T cells [76]