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By reducing MDSC abundance, icaritin elevated CD8 + cytotoxic T cell infiltration, representing a promising adjuvant systemic agent for HCC immunotherapy [217, 218]

Glutathione S-transferase possesses various catalytic activities such as catalytic detoxification and thiol transfer, as well as chaperone function

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The other 3 mice in each group were intravenously injected with pimonidazole hydrochloride (60 mg kg 1 ) (Hypoxyprobe-1 plus kit, Hypoxyprobe Inc.)

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[7] [8] Once internalized, zinc acts as an anti-oxidant surrogate by inducing metallothionein, a cysteine-rich peptide that scavenges free radicals and buffers transition-metal toxicity