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There are several points of the TCA cycle that are critical for NRF2-regulated processes

Research has found that many chronic diseases are associated with a reduction in glutathione levels, leading to the hypothesis that increasing glutathione levels can help prevent and/or mitigate the progression of these diseases

Cold Spring Harb Perspect Biol 10.1101/cshperspect.a040543 [DOI] [PMC free article] [PubMed] [Google Scholar] *.Chandel NS

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118 This leads to mTORC1 suppression, the inhibition of protein synthesis and the activation of autophagy, highlighting a point of convergence between glucose and amino acid sensing in the regulation of mTORC1

Statistical analysis was performed using Metaboanalyst 6.0 ( and a heatmap showing the relative intensity of compounds in the various samples was generated