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In fact, the activity of the multienzyme complex is also sensitive to the energy charge of the cell

221,222 Increased TNF induces IL-27Ra via the ERK-ETS1 pathway, promoting inflammation and further compromising HSC function

5c), indicating the specific association of CTIF, DCTN1 and eEF1A1 with the CT complex under normal conditions, and selective dissociation of these components from the CT complex upon UPS impairment

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From a transfusion standpoint, these discrepancies are notably significant since similar biological processes may yield divergent functional consequences dependent upon the underlying circumstances