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Mandrioli, T.G

M.PapadimitriouA.SilvaK

Protein misfolding and failure of clearance systems, including the autophagy-lysosome and ubiquitin-proteasome pathways, further compromise the cellular environment and lead to toxic intracellular accumulations [31, 32]

During Phase I, enzymes (primarily the cytochrome P450 family) break down toxins, but in doing so, they frequently generate highly reactive intermediate metabolites

To address this issue, a hydrogel-based bioadhesive dry powder has been developed for pulmonary inhalation, with particles smaller than 5 m in diameter, allowing for deeper lung deposition 30,31

doi: 10.1038/s41392-020-00454-7