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Once assembled, the NLRP3 complex triggers GSDMD-mediated pyroptosis, resulting in the release of pro-inflammatory cytokines and amplification of neuroinflammation [103,104,105,106] (Fig

47 The NF-B member c-Rel is particularly important for mediating Treg development, and c-Rel acts by participating in the induction of Treg master transcription factor Foxp3

10.1016/j.tcb.2015.12.002 Trends Cell Biol

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Therefore, the proper maintenance of redox homeostasis can potentially serve as a rational therapeutic strategy to protect against OA progression