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This patient's isolated drop in weight with preserved length strongly points to an early nutritional deficit rather than an intrinsic systemic disease

Based on the December 2025 filing, that puts a decision around OctoberDecember 2026

Given that AGEs are primarily metabolized in the liver and excreted through the kidneys 45,46 , the decline in serum AGEs levels observed here may reflect hepatic metabolism and clearance rather than direct cutaneous effects

Despite these positive signals, the clinical evidence remains limited by several key factors: small sample sizes, heterogeneity in probiotic strains, dosages, and administration routes, short follow-up periods, and a primary focus on BV and VVC rather than HPV clearance as the primary endpoint

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