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TFCP significantly inhibited hepatic lipid accumulation, and enzymes responsible for fat acid synthesis (including HMG-CoA reductase, acetyl-CoA carboxylase, and fatty acid synthase)

S-Adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1

Al binds to the external structure on AtALMT1 which triggers changes in the TM1-2 loop and TM5-6 loop conformational resulting in the opening of the anion gate for malate efflux (Wang et al., 2022)

Lactate and hydrogen ions (H+) are produced during glycolysis and are associated with mitochondrial failure and hypoxia (Ivashkiv, 2020)

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NNMT is a cytosolic enzyme that is primarily expressed in the liver and catalyzes the transfer of methyl group from the cofactor S-(5-adenosyl)-L-methionine (SAM) to other substrates