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When cells respond to chronic hyperglycemia, the expression of NOX enzymes is upregulated, activating angiotensin II type 1 receptor (AT1R) and increasing superoxide production [152153]

10.3389/fphar.2018.00292 16 EnomotoA.ItohK.NagayoshiE.HarutaJ.KimuraT.O'ConnorT.et al (2001)

(2021a, b) in diabetic db/db mice and high glucose-induced HK-2 cells, AC could improve early renal damage induced by DM through regulating TGF-/Smad signaling pathway, which is implicated in regulating renal fibrosis in chronic kidney disease (Wang et al

As compared with non-metastatic set up, LOX expression in human HCC cells was significantly enhanced in metastatic set up after interaction with polarized macrophages in vitro