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Similarly, in a screen of mutant KRAS lung adenocarcinoma cells, HG106 was found to specifically inhibit SLC7A11 function and decrease tumor burden in vivo via ROS induction and mitochondrial and endoplasmic reticulum dysfunction (78)

The paracrine HH ligands include sonic hedgehog (SHH), indian hedgehog (IHH), and desert hedgehog (DHH)

Apply a small amount to clean, dry skin and follow with a moisturiser

Interventions may include the use of mitochondrial-targeted antioxidants and regulators of mitochondrial dynamics to restore normal function and mitigate lung injury (Sheu et al., 2006)

WS and NEF received funding through the NHS Research Scotland Senior Fellowship programme

JAMA Psychiatry 76, 893903