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Second, we are proposing to adopt two new measures, and remove two existing measures

it is especially true for autoimmune connective tissue diseases (e.g., SLE), where some off-label therapies (e.g., rituximab) seem to work in selected cases in the everyday clinical routine but failed to show significant differences over placebo in clinical trials ( Despite the fact that there are many differences in the pathogenesis of systemic autoimmune diseases, many aspects are similar, leading to common molecular targets, like type I IFN/IFN receptor, IL-17, GM-CSF receptor, BAFF, CD40/40L, or JAK/STAT ( Table 2 )

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