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measure ammonia level if unexplained lethargy and vomiting or changes in mental status, and also with concomitant topiramate use

npj Parkinsons Disease 9(1):141 Srivastava S, Karambhe AD, Raut US, Patel A, Narain P, Abedeen MZ et al (2025) Psychological and pharmacological strategies to address sleep disturbances in chronic illness: a review

Specifically, lactate triggers mitochondrial fission 1 (Fis1) lactylation at lysine 20, which promotes excessive mitochondrial fission, leading to ATP depletion, mtROS overproduction, and mitochondrial apoptosis, exacerbating S-AKI

L., Lumeng, L

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Conversely, the SSG of transglutaminase 2 at Cys193 promotes its degradation, sensitizing colon cancer cells to 5-fluorouracil by restoring apoptosis (95)