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For patients in dose-escalation phases, crossing time zones may require dose timing adjustments

A hypocaloric Mediterranean-type diet with probiotics and magnesium and tryptophan supplementation appears to have a beneficial effect on FM

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Meanwhile, the prodrug of triptolide, has been developed in clinical trials for patients with advanced solid tumors (NCT03129139) and refractory pancreatic malignancy (NCT03117920 and NCT04896073)

Arsenic trioxide inhibits the growth of cancer stem cells derived from small cell lung cancer by downregulating stem cell-maintenance factors and inducing apoptosis via the Hedgehog signaling blockade