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As of 2022, the Human Metabolome Database (HMDB Version 5.0) contained 217,920 annotated metabolites, with a further 1,581,537 unannotated derivatized metabolite entries from gas chromatography-mass spectrometry (GC-MS) data (Wishart et al., 2022)

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10 Loop diureticsoften used for other indications, such as hypertension and heart failureincrease urinary potassium excretion at the collecting duct of the kidney

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Nuclear factor erythroid 2-related factor 2 facilitates neuronal glutathione synthesis by upregulating neuronal excitatory amino acid transporter 3 expression