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They proposed that melatonin upregulates antioxidant enzymes, increases distribution of cells in S-phase and decreases G0/G1 cells, reduces lipid peroxidation, all of which could explain its protective mechanism [39]

10.1111/j.1442-9071.2011.02742.x 316

EGCG is an ester formed from epigallocatechin and gallic acid, classified as a type of catechin

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Wang, C.-L

The pentose phosphate pathway (PPP) is the major supply of NADPH in cells and so cells were incubated with 6-amino nicotinamide, a known inhibitor of the PPP enzyme 6-phosphogluconate dehydrogenase