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There are significant inter-ethnic differences in the polymorphism frequency, but it is unclear whether these result in a clinically relevant phenotype (see Table 2 in the supplementary data for a summary of the evidence) [37]

Br J Haematol 155: 125-8, 2011

Researchers evaluate how copper-binding peptides influence signaling coordination, cellular communication, and pathway dynamics

Proc Natl Acad Sci 115:E9668E9677

In some cases of long-term severe deficiency, healing of the nerve damage may be extremely slow, requiring maintenance of B12 levels for months to achieve optimal recovery

The payoff is only there if you track the right metrics instead of running on vibes