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[DOI] [PubMed] [Google Scholar] 62.Qiao L, Zhang H, Yu J, Francisco R, Dent P, Ebert MP

7.2.3 Corticosteroid resistance A subset of patients exhibits glucocorticoid resistance due to chronic Nrf2 activation, which paradoxically enhances ferroptotic susceptibility

doi: 10.1002/1520-6866(2001)21:2 3.0.co;2-v

Ingesta de referencia de un adulto medio (8400 kJ/ 2000 kcal)

318, F96F106

When serum B12 results are equivocal or clinical suspicion remains high despite normal B12 levels, additional tests may be requested: Methylmalonic acid (MMA) : Elevated levels indicate functional B12 deficiency at the cellular level, though availability may be limited in primary care and levels can be elevated in renal impairment Homocysteine : Also elevated in B12 deficiency, though less specific and also affected by renal function Intrinsic factor antibodies : To investigate pernicious anaemia, the most common cause of B12 deficiency in the UK Anti-parietal cell antibodies : May be tested if pernicious anaemia is suspected but intrinsic factor antibodies are negative Identifying the underlying cause is crucial for appropriate management