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Through this unique mechanism, SQOR not only efficiently removes potentially toxic H 2 S (preventing its accumulation in mitochondria), but also plays a central regulatory role in maintaining cellular energy balance and managing oxidative stress, serving as a key junction between sulfur metabolism and bioenergetics (Salti et al., 2024)

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Kim JM, Billington E, Reyes A et al (2019) Impaired CuZn superoxide dismutase (SOD1) and calcineurin (Cn) interaction in ALS: a presumed consequence for TDP-43 and zinc aggregation in Tg SOD1G93A rodent spinal cord tissue

World J Clin Cases (2025) 13(2):96557

Briefly, in a 200 l reaction volume, 5 g ml 1 recombinant GSTO1 in reaction buffer (100 mM Tris (pH 8.0), 1.5 mM EDTA and 1 mM DTT) was incubated with DMSO or different concentrations of inhibitors for 30 min at 37 C

Nature 512:4953 Jung J, Park J, Kim M, Ha J, Cho H, Park SB (2023) SB2301-mediated perturbation of membrane composition in lipid droplets induces lipophagy and lipid droplets ubiquitination