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It is a cluster of overlapping biological dysfunctions that conventional medicines organ-by-organ approach is poorly equipped to address simultaneously

41 Similarly, in a meta-analysis of five clinical trials, vitamin D supplementation (as daily or high bolus doses, with or without calcium) was shown to reduce the risk of BPPV recurrence by 63%

3.7 Mitochondria and autophagosomes Efficient mitophagy depends not only on lysosomal degradation but also on upstream cargo sequestration and vesicle maturation

Oxidative DNA adducts such as 8-oxoG are not only lesions but also contextual signals that recruit base-excision machinery (e.g., OGG1) and remodel local chromatin, thereby coupling genome surveillance to transcriptional tuning