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Specifically, the surface of the gastrointestinal tract is covered by a mucous layer about 50450 m thick, with a pore size of about 501800 nm and a negative charge, forming a complex physicochemical barrier ( Chitosan can enhance the transepithelial permeability of anticancer drugs by temporarily opening tight junctions between epithelial cells ( The carboxyl group on the alginate molecular chain can electrostatically interact with the positively charged protein in the colon mucosa to form a hydrophilic adsorption layer (Figure 2B)