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Description

This mutation results in a glycine-to-aspartate substitution (p.Gly376Asp) in the C-terminal domain [18] of the TAR DNA binding protein 43 (TDP-43 G376D ) and is associated with a fast disease progression and a dominant pattern of transmission with incomplete penetrance

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doi:10.1038/eye.2011.37 9

Pig models with intestinal access that bypasses gastric digestion were used, and ORMD-0801 lowered the AUC of blood glucose levels by 7.0%7.5% in them [64]