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Research across multiple decades has focused on GHK-Cus role in collagen and elastin synthesis, glycosaminoglycan production, wound closure, angiogenesis, and more recently, gene expression modulation where data indicates influence over a remarkably broad range of biological pathways

PMID: 38490470

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Sphingomyelin accumulation in liver, lungs, and other tissues leads to hepatosplenomegaly, pulmonary disease, liver dysfunction, and dyslipidemia in most patients

More recently, advances in phytotherapeutics have highlighted the potential of selected bioactive compounds to modulate key molecular drivers of androgen excess and exhibit anti-androgenic activity

An increase in BMI and abdominal obesity in postmenopausal women show about 5 times higher risk of central obesity compared to premenopausal women [44]