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Owing to the varying duration and progression of BOO lesions, many patients still develop progressive bladder dysfunction and renal impairment after surgery, which are difficult to treat (Wang et al., 2023)

Extending its immune-regulatory and nuclear roles, SHMT2 can directly interact with cytoplasmic p53, inhibiting its binding with the E3 ubiquitin ligase HDM2 and thereby preventing p53 ubiquitination and subsequent degradation (Fig

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Notably, rodent studies have suggested that NMN can effectively enhance NAD + synthesis in peripheral tissues and organs, including the brain [13], blood vessels [14], skeletal muscle [9, 15], adipose tissue [16, 17], pancreas [18], heart [19, 20], liver [9, 21], kidneys [22, 23], and eyes [24, 25], providing several health benefits