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Lin J, Huang N, Li M, et al

doi: 10.1371/journal.pone.0182208

Randomized placebo-controlled trial of reloxaliase in enteric hyperoxaluria

Transient stress or increased cytoplasmic TDP-43 triggers phase separation into toxic cytoplasmic droplets that block nuclear import, deplete nuclear TDP-43, and cause cell death, offering a present mechanistic model for ALS/FTD pathology (Gasset-Rosa et al., 2019)