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On the other hand, while experimental approaches provide valuable insights into the biological effects of nutraceuticals, in silico molecular docking serves as a powerful computational tool to predict and elucidate the binding interactions between these compounds and their molecular targets (119)

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Under certain physiological conditions first described in pregnancy (119, 120), specific proteases cleave IGFBP-3 into several proteolytic fragments of which each may retain immunoactivity and thus give rise to signals in an immunometric assay (121)