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Tumor exosomes could also facilitate organ-specific metastatic behavior by preparing pre-metastatic niches [19, 21]

Although tirzepatide did not meet the criterion for superiority to dulaglutide with respect to the primary endpoint, a prespecified subgroup analysis suggested a possible lower incidence of death from any cause and of death from noncardiovascular causes in the tirzepatide group than in the dulaglutide group

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In addition, encephalopathy or delirium may develop relatively slowly and result in dementia