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Furthermore, IC 50 values in the same cell lines obtained by MTT assay after 72 h of treatment indicated that these compounds were less active than their free ligands (curcumin and bisdemethoxycurcumin) and their precursors Rh III -01 , Ir III -01 , Rh III -01c , and Ir III -01c (Pettinari et al., 2015) (Figure 14)