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doi: 10.1016/j.biocel.2013.12.014 78 HansenMLe NoursJJohanssonEAntalTUllrichALfflerMet al

Unfortunately, there is no validated animal model to recapitulate the human patterns of INH-induced liver injury 6

10.1096/fj.14-268102 FASEB J

Furthermore, MTHFR knockout mice showed a decrease in methionine level, methionine/homocysteine ratio, dimethylglycine level, and lipid deposition in proximal aorta along with changes in cerebellar pathology, reduced cerebellum, reduced cerebral cortex, and developmental issues ( In conclusion, we identified a novel biallelic non-sense mutation in a single affected individual suffering from severe MTHFR deficiency

PMID 17630612