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Figure 1 2.1 Hormonal and endocrine dysregulation Estrogen dependency and progesterone resistance are central to the hormonal and endocrine dysregulation driving endometriosis-associated infertility, facilitating ectopic endometrial implantation through impaired apoptosis, heightened inflammation, and aberrant neuroangiogenesis ( de novo synthesis within ectopic lesions and enhanced estrogen receptor signaling