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Challenges Mitochondrial therapeutics undoubtedly have a positive impact on PD progression

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The proposed mechanisms involve upregulation of growth factors including TGF-beta (at early wound-healing phases), VEGF (angiogenesis), and FGF (fibroblast activation), alongside GHK Cus promotion of extracellular matrix deposition

Author: Yuzhao Huang, Yuchen He , Meagan J

Several novel TGF-1 receptor kinase inhibitors, including SKI2162 [325], vactosertib (EW-7197) [326], galunisertib (LY2157299) [327] and LY2109761 [328], are demonstrated to specifically block the TGF-1 signaling pathway and hence suppress radiation-induced murine pulmonary and skin fibrosis