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NAD + -consuming enzymes include NAD + glycohydrolases (NADases) such as CD38 and sterile alpha and TIR motif containing 1 (SARM1), deacylases (sirtuins), and ADP-ribosyl transferases (PARPs)

Microbes and their metabolites are involved in regulating the mucosal immunity of the respiratory system, maintaining the integrity of the respiratory epithelial barrier, and resisting the invasion of pathogenic bacteria ( Pseudomonas and Streptococcus ( Haemophilus influenzae leads to more severe infiltration of inflammatory mediators in the lung tissue of COPD mice, and the imbalance of the intestinal microbiota is also associated with the levels of inflammatory cytokines in the lungs

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High-throughput, sequence-based analysis of the microbiota of Greek kefir grains from two geographic regions