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Its particularly beneficial for individuals experiencing fatigue or B12 deficiency, common in strict vegetarians, older adults, or those with certain medical conditions

Increasing levels of VitB12 in humans have been shown to lead to a decline in 24-h mean melatonin levels and nocturnal melatonin levels during bright-light exposure, thereby disrupting the sleep-wake cycle toward increased alertness and decreased sleep duration [21, 38]

Ascorbate is then regenerated by the selenoenzyme thioredoxin reductase

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However, few large scale clinical trials have assessed the efficacy of dietary sulfur amino acids in reducing oxidative stress