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While both of these molecules are potent and their GH-releasing activity is dose-dependent, Hexarelin has been found to influence the levels of prolactin-releasing activity, and Ipamorelin has not been to [5, 6, 8, 9]

[5] previously evaluated the separate roles of insulin and IGF-1 in directly regulating GH secretion, using the Cre/loxP system to knock down the insulin receptor (INSR) and IGF-1 receptor (IGFIR) in primary mouse pituitary cell cultures

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Unlike its parent protein, fragment 176-191 has been found to avoid certain effects, such as increasing insulin-like growth factor-1 (IGF-1) levels, affecting carbohydrate metabolism, reducing insulin sensitivity, and promoting long bone growth