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Lastly, athletic performance may also be influenced by glutathione status, as muscle activity increases reactive oxygen and nitrogen species, utilizing GSH in the process

doi: 10.3389/fimmu.2026.1845654 Received 02 April 2026 Revised 07 April 2026 Accepted 21 April 2026 Published 11 May 2026 Volume 17 - 2026 Edited by Venkata Ramireddy Narala, Yogi Vemana University, India Reviewed by Farrah Kheradmand, Baylor College of Medicine, United States Homayon Ghiasi, Cedars Sinai Medical Center, United States Updates Copyright 2026 Cain, Hurrell, Shen, Speliakos and Akbari

For instance, one study has demonstrated that endogenous DNMT3A and DNMT3B are associated with HDAC activity, where DNMT3A facilitates transcriptional repression via specific molecular interactions between its ATRX-like PHD domain and both HDAC1 and the co-repressor RP58 (302)

Glutathione, often called the bodys master antioxidant, works at the cellular level to support detoxification and skin health, while Astaxanthin enhances antioxidant protection for visible and long-term benefits

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Generally, p53 is considered as a stress responsive protein that activates different downstream pathways depending on the magnitude, duration, and type of upstream stressors