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Immunological and toxicological risk assessment of e-cigarettes

Curr Opin Genet Dev 7:7579 Bourne HR, Sanders DA, McCormick F (1991) The GTPase superfamily: conserved structure and molecular mechanism

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IGF-I binds to three receptors, and the binding to IGFIR promotes cell proliferation, survival, differentiation, and migration

It inhibits bone morphogenetic protein-2 (BMP-2), a driver of vascular mineralization (94)

Both GPX1 expression and activity were substantially lower in mice fed a selenium-deficient diet than those in mice fed a normal diet, leading to decreased trabecular number, reduced femoral trabecular volume/total bone volume ratio, and trabecular separation 66